File:Mantle cell lymphoma - intermed mag.jpg

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Summary

Intermediate magnification <a href="https://en.wikipedia.org/wiki/micrograph" class="extiw" title="w:micrograph">micrograph</a> of <a href="https://en.wikipedia.org/wiki/mantle_cell_lymphoma" class="extiw" title="w:mantle cell lymphoma">mantle cell lymphoma</a> of the <a href="https://en.wikipedia.org/wiki/terminal_ileum" class="extiw" title="w:terminal ileum">terminal ileum</a>. <a href="https://en.wikipedia.org/wiki/biopsy" class="extiw" title="w:biopsy">Endoscopic biopsy</a>. <a href="https://en.wikipedia.org/wiki/H%26E_stain" class="extiw" title="w:H&E stain">H&E stain</a>.

Histomorphologic features:

  • Monomorphic small lymphoid cells less than twice the size of a resting lymphocyte.
  • Abundant mitoses.
  • Sclerosed blood vessels.
  • Scattered epithelioid histiocytes.

Immunohistochemical staining:

  • Positive: Cyclin D1, CD5, CD43, CD20, CD45.
  • Negative: CD23.

Molecular features:

  • t(11;14)(q13;q32).
    • CCND1/IGHG1 fusion gene.<a href="#cite_note-1">[1]</a>

E

Related images

References

  1. <a href="#cite_ref-1">↑</a> URL: <a rel="nofollow" class="external free" href="http://www.ncbi.nlm.nih.gov/omim/168461">http://www.ncbi.nlm.nih.gov/omim/168461</a>. Accessed on: 18 August 2010.

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File history

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Date/TimeThumbnailDimensionsUserComment
current00:47, 7 January 2017Thumbnail for version as of 00:47, 7 January 20172,848 × 4,272 (4.12 MB)127.0.0.1 (talk)Intermediate magnification <a href="https://en.wikipedia.org/wiki/micrograph" class="extiw" title="w:micrograph">micrograph</a> of <b><a href="https://en.wikipedia.org/wiki/mantle_cell_lymphoma" class="extiw" title="w:mantle cell lymphoma">mantle cell lymphoma</a></b> of the <a href="https://en.wikipedia.org/wiki/terminal_ileum" class="extiw" title="w:terminal ileum">terminal ileum</a>. <a href="https://en.wikipedia.org/wiki/biopsy" class="extiw" title="w:biopsy">Endoscopic biopsy</a>. <a href="https://en.wikipedia.org/wiki/H%26E_stain" class="extiw" title="w:H&E stain">H&E stain</a>. <p>Histomorphologic features: </p> <ul> <li>Monomorphic small lymphoid cells less than twice the size of a resting lymphocyte.</li> <li>Abundant mitoses.</li> <li>Sclerosed blood vessels.</li> <li>Scattered epithelioid histiocytes.</li> </ul> <p>Immunohistochemical staining: </p> <ul> <li>Positive: Cyclin D1, CD5, CD43, CD20, CD45.</li> <li>Negative: CD23.</li> </ul> <p>Molecular features: </p> <ul><li>t(11;14)(q13;q32). <ul><li>CCND1/IGHG1 fusion gene.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1">[1]</a></sup> </li></ul> </li></ul> <p>E </p> <h2><span class="mw-headline" id="Related_images">Related images</span></h2> <ul class="gallery mw-gallery-traditional"> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Mantle_cell_lymphoma_-_low_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/0/05/Mantle_cell_lymphoma_-_low_mag.jpg/120px-Mantle_cell_lymphoma_-_low_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/0/05/Mantle_cell_lymphoma_-_low_mag.jpg/180px-Mantle_cell_lymphoma_-_low_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/0/05/Mantle_cell_lymphoma_-_low_mag.jpg/240px-Mantle_cell_lymphoma_-_low_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Low mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:15px auto;"><a href="//commons.wikimedia.org/wiki/File:Mantle_cell_lymphoma_-_intermed_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/0/08/Mantle_cell_lymphoma_-_intermed_mag.jpg/80px-Mantle_cell_lymphoma_-_intermed_mag.jpg" width="80" height="120" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/0/08/Mantle_cell_lymphoma_-_intermed_mag.jpg/120px-Mantle_cell_lymphoma_-_intermed_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/0/08/Mantle_cell_lymphoma_-_intermed_mag.jpg/160px-Mantle_cell_lymphoma_-_intermed_mag.jpg 2x" data-file-width="2848" data-file-height="4272"></a></div></div> <div class="gallerytext"> <p>Intermed. mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Mantle_cell_lymphoma_-_low_mag_-_cyclin_D1.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/8/84/Mantle_cell_lymphoma_-_low_mag_-_cyclin_D1.jpg/120px-Mantle_cell_lymphoma_-_low_mag_-_cyclin_D1.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/8/84/Mantle_cell_lymphoma_-_low_mag_-_cyclin_D1.jpg/180px-Mantle_cell_lymphoma_-_low_mag_-_cyclin_D1.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/8/84/Mantle_cell_lymphoma_-_low_mag_-_cyclin_D1.jpg/240px-Mantle_cell_lymphoma_-_low_mag_-_cyclin_D1.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Low mag. - cyclin D1. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:15px auto;"><a href="//commons.wikimedia.org/wiki/File:Mantle_cell_lymphoma_-_intermed_mag_-_cyclin_D1.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/a/af/Mantle_cell_lymphoma_-_intermed_mag_-_cyclin_D1.jpg/80px-Mantle_cell_lymphoma_-_intermed_mag_-_cyclin_D1.jpg" width="80" height="120" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/a/af/Mantle_cell_lymphoma_-_intermed_mag_-_cyclin_D1.jpg/120px-Mantle_cell_lymphoma_-_intermed_mag_-_cyclin_D1.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/a/af/Mantle_cell_lymphoma_-_intermed_mag_-_cyclin_D1.jpg/160px-Mantle_cell_lymphoma_-_intermed_mag_-_cyclin_D1.jpg 2x" data-file-width="2848" data-file-height="4272"></a></div></div> <div class="gallerytext"> <p>Intermed. mag. - cyclin D1. </p> </div> </div></li> </ul> <h2><span class="mw-headline" id="References">References</span></h2> <div class="reflist references-column-count references-column-count-1" style="-moz-column-count: 1; -webkit-column-count: 1; column-count: 1; list-style-type: decimal;"> <ol class="references"> <li id="cite_note-1"> <span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text">URL: <a rel="nofollow" class="external free" href="http://www.ncbi.nlm.nih.gov/omim/168461">http://www.ncbi.nlm.nih.gov/omim/168461</a>. Accessed on: 18 August 2010.</span> </li> </ol> </div>
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