Hemin

Hemin
Systematic (IUPAC) name
	Chloro[3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-dipropanoato(2−)]iron(III)
Clinical data
AHFS/Drugs.com	Consumer Drug Information
Pregnancy; category	US: C (Risk not ruled out); ;
Legal status	US: ℞-only;
Routes of; administration	Intravenous infusion
Identifiers
CAS Number	16009-13-5
ATC code	B06AB01 (WHO)
PubChem	CID: 5318002
ChemSpider	21160444
UNII	743LRP9S7N
ChEMBL	CHEMBL1628226
Chemical data
Formula	C34H32ClFeN4O4
Molecular mass	651.94 g/mol
	SMILES OC(=O)CCC=5C1=C\C6=N\C(=C/c3n2[Fe](Cl)N1C(=C\C4=N\C(=C/c2c(C=C)c3C)C(/C)=C4/C=C)/C=5C)C(\C)=C6\CCC(O)=O ;
	InChI InChI=1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16?;; ; Key:BTIJJDXEELBZFS-UKFHATERSA-K ;
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Hemin (trade name Panhematin) is an iron-containing porphyrin.^[1] More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand.

It is used in the management of porphyria attacks, particularly in acute intermittent porphyria.

It is sometimes distinguished from hematin which has a hydroxide ligand in place of the chloride. However, the terms are sometimes equated.^[2]

Hematin is considered the "X factor" required for the growth of Haemophilus influenzae.^[3]

References

Information from the American Porphyria Foundation, including emergency delivery information
Hemin at RxList
Hemin at the US National Library of Medicine Medical Subject Headings (MeSH)