Lamellar granule
Lamellar granules (otherwise known as membrane-coating granules (MCGs), lamellar bodies, keratinosomes or Odland bodies) are secretory organelles found in type II pneumocytes and keratinocytes. They are oblong structures, appearing about 300-400 nm in width and 100-150 nm in length in transmission electron microscopy images. Lamellar granules fuse with the cell membrane and release their contents into the extracellular space.[1]
Role in lungs
In pneumocytes, the choline-based phospholipids that are stored in the lamellar bodies serve as pulmonary surfactant after being released from the cell. In 1964, using transmission electron microscopy, which at that time was a relatively new tool for ultrastructural elucidation, John Balis identified the presence of lamellar bodies in type II pneumocytes, and further noted that upon their exocytotic migration to the alveolar surface, lamellar contents would uniformly unravel and spread along the circumference of the alveolus, thus lowering surface tension and similarly, the required alveolar inflation force.[2]
Role in epidermis
In the upper spinous layer and stratum granulosum layer of the epidermis, lamellar bodies are secreted from keratinocytes, resulting in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function. These granules release components that are required for skin shedding (desquamation) in the uppermost epidermal layer, the stratum corneum.[3] These components include lipids (e.g. glucosylceramides), hydrolytic enzymes (e.g. proteases, acid phosphatases, glucosidases, lipases) and proteins (e.g. corneodesmosin).[4] Lamellar granules have been observed to contain distinct aggregates of the secreted components glucosylceramide, cathepsin D, KLK7, KLK8 and corneodesmosin. Transportation of molecules via lamellar granules is thought to prevent enzymes from interacting with their relevant substrates or inhibitors prior to secretion.[4]
Recent work suggests that lamellar granules form a continuous membranous structure with the trans-Golgi network
Lamellar body secretion and lipid structure is abnormal in the epidermis of patients with Netherton syndrome, a skin disorder characterised by chronic inflammation and universal pruritus (itch).[5]
References
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- ↑ Balis J.U., Conen P.E. (Oct 1964), "The Role of Alveolar Inclusion Bodies in the Developing Lung." Lab Invest. 13:1215-29. PMID 14212352.
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