Inhibitor of apoptosis domain
Inhibitor of Apoptosis domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
File:1QBH BIRC2.png
NMR solution structure of the BIR domain of human BIRC2 protein.[1] The protein is rainbow colored cartoon diagram (N-terminus = blue, C-terminus = red) while the coordinated zinc is represented by a grey sphere.
|
|||||||||
Identifiers | |||||||||
Symbol | BIR | ||||||||
Pfam | PF00653 | ||||||||
InterPro | IPR001370 | ||||||||
PROSITE | PS50143 | ||||||||
SCOP | 1qbh | ||||||||
SUPERFAMILY | 1qbh | ||||||||
|
The inhibitor of apoptosis domain -- also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR -- is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation.[2] Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins (BIRPs or BIRCs), and include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6.[2][3]
BIR domains belong to the zinc-finger domain family and characteristically have a number of invariant amino acid residues, including 3 conserved cysteines and one conserved histidine, which coordinate a zinc ion.[4] They are typically composed of 4-5 alpha helices and a three-stranded beta sheet.
External links
- Eukaryotic Linear Motif resource motif class LIG_BIR_II_1
- Eukaryotic Linear Motif resource motif class LIG_BIR_III_1
- Eukaryotic Linear Motif resource motif class LIG_BIR_III_2
- Eukaryotic Linear Motif resource motif class LIG_BIR_III_3
- Eukaryotic Linear Motif resource motif class LIG_BIR_III_4
References
This article incorporates text from the public domain Pfam and InterPro IPR001370