CHRNA6

Cholinergic receptor, nicotinic, alpha 6 (neuronal)
Identifiers
Symbols	CHRNA6 ; CHNRA6
External IDs	OMIM: 606888 MGI: 106213 HomoloGene: 20888 IUPHAR: 467 ChEMBL: 2356 GeneCards: CHRNA6 Gene
Gene ontology Molecular function • acetylcholine-activated cation-selective channel activity • acetylcholine receptor activity • acetylcholine binding Cellular component • plasma membrane • acetylcholine-gated channel complex • cell junction • neuron projection • synapse • postsynaptic membrane Biological process • transport • signal transduction • synaptic transmission • synaptic transmission, cholinergic • neuromuscular synaptic transmission • regulation of dopamine secretion • response to nicotine • regulation of membrane potential • neurological system process • membrane depolarization • cation transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CHRNA6 207568 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8973	11440
Ensembl	ENSG00000147434	ENSMUSG00000031491
UniProt	Q15825	Q9R0W9
RefSeq (mRNA)	NM_001199279	NM_021369
RefSeq (protein)	NP_001186208	NP_067344
Location (UCSC)	Chr 8: 42.75 – 42.8 Mb	Chr 8: 27.4 – 27.41 Mb
PubMed search	[1]	[2]

Cholinergic receptor, nicotinic, alpha 6, also known as CHRNA6, is a human gene, which codes for the α6 subunit found in certain types of nicotinic acetylcholine receptors found primarily in the brain. Neural nicotinic acetylcholine receptors containing α6 subunits are expressed on dopamine-releasing neurons in the midbrain, and dopamine release following activation of these neurons is thought to be involved in the addictive properties of nicotine. Due to their selective localisation on dopaminergic neurons, α6-containing nACh receptors have also been suggested as a possible therapeutic target for the treatment of Parkinson's disease.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]

File:NicotineDopaminergic_WP1602.png

Nicotine Activity on Dopaminergic Neurons edit

See also

• Nicotinic acetylcholine receptor

External links

• CHRNA6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.