Cartilage oligomeric matrix protein
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In humans it is encoded by the COMP gene.[1][2][3]
Function
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein.[4] It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).[3]
COMP is a marker of cartilage turnover.[5] It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling.[6]
References
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Further reading
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External links
- GeneReviews/NCBI/NIH/UW entry on Pseudoachondroplasia
- GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant
- cartilage matrix protein at the US National Library of Medicine Medical Subject Headings (MeSH)
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