FRAS1

Fraser extracellular matrix complex subunit 1
Identifiers
Symbols	FRAS1 ; DKFZp686I05113; DKFZp686P08111; FLJ14927; FLJ22031; KIAA1500
External IDs	OMIM: 607830 MGI: 2385368 HomoloGene: 23516 GeneCards: FRAS1 Gene
Gene ontology Molecular function • metal ion binding Cellular component • plasma membrane • integral component of membrane • extracellular matrix • sublamina densa Biological process • morphogenesis of an epithelium • metanephros morphogenesis • cell communication • protein transport • embryonic limb morphogenesis • skin development • palate development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80144	231470
Ensembl	ENSG00000138759	ENSMUSG00000034687
UniProt	Q86XX4	Q80T14
RefSeq (mRNA)	NM_001166133	NM_175473
RefSeq (protein)	NP_001159605	NP_780682
Location (UCSC)	Chr 4: 78.06 – 78.54 Mb	Chr 5: 96.37 – 96.78 Mb
PubMed search	[1]	[2]

Extracellular matrix protein FRAS1 is a protein that in humans is encoded by the FRAS1 (Fraser syndrome 1) gene. This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development.

Clinical significance

Mutations in this gene is observed to cause fraser syndrome.

See also

• Fraser syndrome