Condensation domain
From Infogalactic: the planetary knowledge core
| Condensation | |||||||||
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| File:PDB 1l5a EBI.jpg
crystal structure of vibh, an nrps condensation enzyme
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| Identifiers | |||||||||
| Symbol | Condensation | ||||||||
| Pfam | PF00668 | ||||||||
| Pfam clan | CL0149 | ||||||||
| InterPro | IPR001242 | ||||||||
| SCOP | 1l5a | ||||||||
| SUPERFAMILY | 1l5a | ||||||||
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In molecular biology, the condensation domain is a protein domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG sequence motif in this domain abolish activity suggesting this is part of the active site.[1]
References
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This article incorporates text from the public domain Pfam and InterPro IPR001242
