IKZF4

IKAROS family zinc finger 4 (Eos)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2MA7
Identifiers
Symbols	IKZF4 ; EOS; ZNFN1A4
External IDs	OMIM: 606239 MGI: 1343139 HomoloGene: 69103 GeneCards: IKZF4 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • protein homodimerization activity • bHLH transcription factor binding • sequence-specific DNA binding • metal ion binding • protein heterodimerization activity Cellular component • nucleus Biological process • transcription, DNA-templated • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE IKZF4 208472 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64375	22781
Ensembl	ENSG00000123411	ENSMUSG00000002578
UniProt	Q9H2S9	Q8C208
RefSeq (mRNA)	NM_022465	NM_011772
RefSeq (protein)	NP_071910	NP_035902
Location (UCSC)	Chr 12: 56.01 – 56.04 Mb	Chr 10: 128.63 – 128.65 Mb
PubMed search	[1]	[2]

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM]

Interactions

IKZF4 has been shown to interact with CTBP1 and IKZF1.