IKZF1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). DNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene.[1][2][3] Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia.[4] In particular, Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia.[4] IKZF1 is upregulated in granulocytes, B cells, CD4 and CD8 T cells, and NK cells, and downregulated in erythroblasts, megakaryocytes and monocytes.[5] In Ikaros knockout mice, T cells but not B cells are generated late in mouse development due to late compensatory expression of the related gene Aiolos (IKZF3).[6] Ikaros point mutant mice are embryonic lethal due to anemia; they have severe defects in terminal erythrocyte and granulocyte differentiation, and excessive macrophage formation.[7] SNPs located near the 3' region of IKZF1 in humans have been linked to susceptibility to childhood acute lymphoblastic leukemia (ALL) [8] as well as type 1 diabetes.[9] The two effects appear to be in opposite directions, with the allele marking susceptibility to ALL protecting from T1D and vice versa.[9]
Interactions
IKZF1 has been shown to interact with:
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References
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Further reading
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External links
- IKZF1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- IKZF1 human gene location in the UCSC Genome Browser.
- IKZF1 human gene details in the UCSC Genome Browser.
