Lymphocyte cytosolic protein 2

Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
250px Rendering of 1H3H
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1H3H, 1YWO, 2EAP, 2ROR
Identifiers
Symbols	LCP2 ; SLP-76; SLP76
External IDs	OMIM: 601603 MGI: 1321402 HomoloGene: 4065 GeneCards: LCP2 Gene
Gene ontology Molecular function • protein binding Cellular component • cytosol • cell-cell junction • TCR signalosome • plasma membrane raft Biological process • immune response • transmembrane receptor protein tyrosine kinase signaling pathway • blood coagulation • platelet activation • intracellular signal transduction • Fc-epsilon receptor signaling pathway • innate immune response • mast cell activation • positive regulation of protein kinase activity • cytokine secretion • T cell receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE LCP2 205269 at tn.png
File:PBB GE LCP2 205270 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3937	16822
Ensembl	ENSG00000043462	ENSMUSG00000002699
UniProt	Q13094	Q60787
RefSeq (mRNA)	NM_005565	NM_010696
RefSeq (protein)	NP_005556	NP_034826
Location (UCSC)	Chr 5: 170.25 – 170.3 Mb	Chr 11: 34.05 – 34.09 Mb
PubMed search	[1]	[2]

Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa), also known as LCP2 or SLP-76, is a gene that encodes a signal-transducing adaptor protein.

Structure

No full structure for SLP-76 has been solved. The PDB file 1H3H depicts the SH3 domain of GRAP2 in complex with an RSTK-containing peptide representing residues 226-235 of SLP-76.

Function

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and composed of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues that are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Interactions

Lymphocyte cytosolic protein 2 has been shown to interact with:

• Cbl gene,
• GRAP2,
• Grb2,
• ITK
• LYN,
• NCK1,
• PIK3R1,
• PLCG1,
• PTPN6,
• SHB, and
• VAV1.

See also

• T cell activation

External links

• SLP-76 signal Transducing adaptor proteins at the US National Library of Medicine Medical Subject Headings (MeSH)