PRPF8
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene.[1][2]
Function
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa.[3]
Interactions
PRPF8 has been shown to interact with WDR57[4][5] and EFTUD2.[5]
References
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Further reading
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External links
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