Quadrosilan

Quadrosilan
Systematic (IUPAC) name
	2,2,4,6,6,8-Hexamethyl-4,8-diphenyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
Identifiers
CAS Number	4657-20-9
PubChem	CID: 20774
ChemSpider	19557
Synonyms	Quadrosilane
Chemical data
Formula	C18H28O4Si4
Molecular mass	420.106466 g/mol
	SMILES C[Si]1(O[Si](O[Si](O[Si](O1)(C)C2=CC=CC=C2)(C)C)(C)C3=CC=CC=C3)C ;
	InChI InChI=1S/C18H28O4Si4/c1-23(2)19-25(5,17-13-9-7-10-14-17)21-24(3,4)22-26(6,20-23)18-15-11-8-12-16-18/h7-16H,1-6H3 ; Key:ZTQZMPQJXABFNC-UHFFFAOYSA-N ;

Quadrosilan (INN, BAN) (trade name Cisobitan; former developmental code name KABI-1774) is a synthetic, non-steroidal estrogen that was developed in the 1970s and that is or has been used as an antigonadotropic agent in the treatment of prostate cancer.^[1]^[2]^[3]^[4] It is an organosilicon compound, and is also known as 2,6-cisdiphenylhexamethylcyclotetrasiloxane.^[3]^[5] Quadrosilan has estrogenic activity equivalent to that of estradiol,^[6] and can produce feminization and gynecomastia as side effects in male patients.^[7]^[8]

References