Estropipate
From Infogalactic: the planetary knowledge core
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Systematic (IUPAC) name | |
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[(8R,9S,13S,14S)-13-Methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate; piperazine
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Clinical data | |
AHFS/Drugs.com | monograph |
Identifiers | |
CAS Number | 7280-37-7 ![]() |
ATC code | none |
PubChem | CID: 5284555 |
DrugBank | DB04574 ![]() |
ChemSpider | 4447610 ![]() |
UNII | SVI38UY019 ![]() |
KEGG | D00948 ![]() |
ChEMBL | CHEMBL1200980 ![]() |
Chemical data | |
Formula | C22H32N2O5S |
Molecular mass | 436.56 g/mol |
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Estropipate (INN, BAN) (brand names Ogen, Ortho-Est), also known as piperazine estrone sulfate, is a synthetic, steroidal estrogen. It is a salt of estrone sulfate and piperazine.
Contents
Uses
Estropipate is used to:
- Alleviate symptoms of menopause as hormone replacement therapy
- Treat some types of infertility
- Treat some conditions leading to underdevelopment of female sexual characteristics
- Treat vaginal atrophy
- Treat some types of breast cancer (particularly in men and postmenopausal women)
- Treat prostate cancer
- Prevent osteoporosis
Pharmacology
Estropipate is an agonist of the estrogen receptor (ER). In addition, estropipate has been found to act as an inhibitor of OATP1B1 (IC50 = 70 nM).[1]
See also
References
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