SH3KBP1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). SH3 domain-containing kinase-binding protein 1 is an enzyme that in humans is encoded by the SH3KBP1 gene.[1][2]
CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM][3]
Interactions
SH3KBP1 has been shown to interact with B-cell linker,[4] Grb2,[5][6] SH3GLB2,[7][8] SH3GL3,[7] SH3GL2,[8] BCAR1,[4] Epidermal growth factor receptor,[8][9] CBLB,[9] Cbl gene,[4][6][7][8][9] SOS1,[4] CRK[4] and PAK2.[10]
References
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Further reading
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