Adapter molecule crk

V-crk avian sarcoma virus CT10 oncogene homolog
250px PDB rendering based on 1b07.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1JU5, 2DVJ, 2EYV, 2EYW, 2EYX, 2EYY, 2EYZ
Identifiers
Symbols	CRK ; CRKII; p38
External IDs	OMIM: 164762 MGI: 88508 HomoloGene: 81850 ChEMBL: 5005 GeneCards: CRK Gene
Gene ontology Molecular function • SH3/SH2 adaptor activity • protein binding • SH2 domain binding • protein phosphorylated amino acid binding • ephrin receptor binding Cellular component • nucleus • cytoplasm • cytosol • plasma membrane • actin cytoskeleton • extracellular exosome Biological process • activation of MAPKK activity • regulation of transcription from RNA polymerase II promoter • blood coagulation • insulin receptor signaling pathway • platelet activation • regulation of actin cytoskeleton organization • regulation of Rac protein signal transduction • Fc-gamma receptor signaling pathway involved in phagocytosis • regulation of GTPase activity • innate immune response • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • ephrin receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CRK 202224 at tn.png
File:PBB GE CRK 202225 at tn.png
File:PBB GE CRK 202226 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1398	12928
Ensembl	ENSG00000167193	ENSMUSG00000017776
UniProt	P46108	Q64010
RefSeq (mRNA)	NM_005206	NM_001277219
RefSeq (protein)	NP_005197	NP_001264148
Location (UCSC)	Chr 17: 1.42 – 1.46 Mb	Chr 11: 75.68 – 75.71 Mb
PubMed search	[1]	[2]

Adapter molecule crk also known as proto-oncogene c-Crk or p38 is a protein that in humans is encoded by the CRK gene.

The CRK protein participates in the Reelin signaling cascade downstream of DAB1.

Function

Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Crk together with CrkL participates in the Reelin signaling cascade downstream of DAB1.

v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains of cellular Crk. The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells.

Crk should not be confused with Src, which also has cellular (c-Src) and viral (v-Src) forms and is involved in some of the same signaling pathways but is a protein tyrosine-kinase.

Interactions

CRK (gene) has been shown to interact with:

• BCAR1,
• Cbl gene,
• Dock180,
• EPS15,
• Epidermal growth factor receptor,
• Grb2,
• IRS4,
• MAP4K1,
• MAPK8,
• NEDD9,
• PDGFRA,
• PDGFRB,
• PTK2,
• Paxillin
• RAPGEF1,
• RICS,
• SH3KBP1, and
• SOS1.

See also

• CrkL, "Crk-like" protein

External links

• Crk Info with links in the Cell Migration Gateway
• Proto-Oncogene Proteins c-crk at the US National Library of Medicine Medical Subject Headings (MeSH)
• Oncogene Protein v-crk at the US National Library of Medicine Medical Subject Headings (MeSH)