SNX4

Sorting nexin 4
Identifiers
Symbols	SNX4 ; ATG24B
External IDs	OMIM: 605931 MGI: 1916400 HomoloGene: 36143 GeneCards: SNX4 Gene
Gene ontology Molecular function • epidermal growth factor receptor binding • insulin receptor binding • protein binding • phosphatidylinositol binding • transferrin receptor binding • leptin receptor binding Cellular component • cytoplasm • endosome • cytoplasmic dynein complex • plasma membrane • membrane • extrinsic component of membrane • SNARE complex • early endosome membrane • protein complex Biological process • endocytosis • protein transport • vesicle organization • endocytic recycling • positive regulation of histamine secretion by mast cell Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE SNX4 212652 s at tn.png
File:PBB GE SNX4 205329 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8723	69150
Ensembl	ENSG00000114520	ENSMUSG00000022808
UniProt	O95219	Q91YJ2
RefSeq (mRNA)	NM_003794	NM_080557
RefSeq (protein)	NP_003785	NP_542124
Location (UCSC)	Chr 3: 125.45 – 125.52 Mb	Chr 16: 33.25 – 33.3 Mb
PubMed search	[1]	[2]

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.

Interactions

SNX4 has been shown to interact with BIN1.