SOX1
From Infogalactic: the planetary knowledge core
| SRY (sex determining region Y)-box 1 | |
|---|---|
| Identifiers | |
| Symbol | SOX1 |
| Entrez | 6656 |
| HUGO | 11189 |
| OMIM | 602148 |
| RefSeq | NM_005986 |
| UniProt | O00570 |
| Other data | |
| Locus | Chr. 13 q34 |
SOX1 (for Sex determining region Y-box 1) is a transcription factor in the Sox protein family. SOX1 expression is restricted to neuroectoderm in the tetrapod embryo.[1][2] SOX1 is involved in early central nervous system development, where it is functionally redundant with SOX3 and to a lesser degree SOX2, and maintenance of neural progenitor cell identity. SOX1 is expressed particularly in the ventral striatum, and Sox1-deficient mice have altered striatum development, leading e.g. to epilepsy.[1]
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