STX1A

Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.^[1]

Function

Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process.

Syntaxin-1A is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. Syntaxin-1A is a key protein in ion channel regulation and synaptic exocytosis.^[2]

Clinical significance

Syntaxins serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis.^[3]

The expression level of STX1A is directly correlated with intelligence in Williams Syndrome.^[4]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

[[File:

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]

File:NicotineDopaminergic_WP1602.png

Nicotine Activity on Dopaminergic Neurons edit

↑ The interactive pathway map can be edited at WikiPathways: Lua error in package.lua at line 80: module 'strict' not found.

Interactions

STX1A has been shown to interact with:

CPLX1,^[5]^[6]^[7]
CFTR,^[8]^[9]
NAPA,^[10]^[11]
RNF40,^[12]
SCNN1G,^[13]
SLC6A1,^[14]^[15]^[16]
SNAP-25,^[5]^[6]^[10]^[17]^[18]^[19]^[20]^[21]^[22]^[23]^[24]
SNAP23,^[22]^[24]^[25]^[26]^[27]
STXBP1,^[5]^[10]^[18]^[28]^[29]
STXBP5,^[30]^[31]
SYT1^[32]^[33]
UNC13B,^[34]
VAMP2,^[5]^[6]^[10]^[29]^[35]^[36] and
VAMP8.^[37]

References

↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ ^5.0 ^5.1 ^5.2 ^5.3 Lua error in package.lua at line 80: module 'strict' not found.
↑ ^6.0 ^6.1 ^6.2 Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ ^10.0 ^10.1 ^10.2 ^10.3 Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ ^18.0 ^18.1 Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ ^22.0 ^22.1 Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ ^24.0 ^24.1 Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ ^29.0 ^29.1 Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.

Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.
Lua error in package.lua at line 80: module 'strict' not found.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[WikiPathways-5] The interactive pathway map can be edited at WikiPathways: Lua error in package.lua at line 80: module 'strict' not found.

[pmid1321498-1] Lua error in package.lua at line 80: module 'strict' not found.

[2] Lua error in package.lua at line 80: module 'strict' not found.

[pmid7622072-3] Lua error in package.lua at line 80: module 'strict' not found.

[pmid20422020-4] Lua error in package.lua at line 80: module 'strict' not found.

[pmid10449403-6] 5.0 ^5.1 ^5.2 ^5.3 Lua error in package.lua at line 80: module 'strict' not found.

[pmid11832227-7] 6.0 ^6.1 ^6.2 Lua error in package.lua at line 80: module 'strict' not found.

[pmid12200427-8] Lua error in package.lua at line 80: module 'strict' not found.

[pmid9384384-9] Lua error in package.lua at line 80: module 'strict' not found.

[pmid12209004-10] Lua error in package.lua at line 80: module 'strict' not found.

[pmid7553862-11] 10.0 ^10.1 ^10.2 ^10.3 Lua error in package.lua at line 80: module 'strict' not found.

[pmid7622514-12] Lua error in package.lua at line 80: module 'strict' not found.

[pmid12121982-13] Lua error in package.lua at line 80: module 'strict' not found.

[pmid14996668-14] Lua error in package.lua at line 80: module 'strict' not found.

[pmid9698305-15] Lua error in package.lua at line 80: module 'strict' not found.

[pmid11960023-16] Lua error in package.lua at line 80: module 'strict' not found.

[pmid11017172-17] Lua error in package.lua at line 80: module 'strict' not found.

[pmid16169070-18] Lua error in package.lua at line 80: module 'strict' not found.

[pmid7768895-19] 18.0 ^18.1 Lua error in package.lua at line 80: module 'strict' not found.

[pmid10954418-20] Lua error in package.lua at line 80: module 'strict' not found.

[pmid10195194-21] Lua error in package.lua at line 80: module 'strict' not found.

[pmid11524423-22] Lua error in package.lua at line 80: module 'strict' not found.

[pmid8663154-23] 22.0 ^22.1 Lua error in package.lua at line 80: module 'strict' not found.

[pmid7961655-24] Lua error in package.lua at line 80: module 'strict' not found.

[pmid9852078-25] 24.0 ^24.1 Lua error in package.lua at line 80: module 'strict' not found.

[pmid12828989-26] Lua error in package.lua at line 80: module 'strict' not found.

[pmid12651853-27] Lua error in package.lua at line 80: module 'strict' not found.

[pmid9168999-28] Lua error in package.lua at line 80: module 'strict' not found.

[pmid12963086-29] Lua error in package.lua at line 80: module 'strict' not found.

[pmid12093152-30] 29.0 ^29.1 Lua error in package.lua at line 80: module 'strict' not found.

[pmid12832401-31] Lua error in package.lua at line 80: module 'strict' not found.

[pmid9620695-32] Lua error in package.lua at line 80: module 'strict' not found.

[pmid9010211-33] Lua error in package.lua at line 80: module 'strict' not found.

[pmid10397765-34] Lua error in package.lua at line 80: module 'strict' not found.

[pmid8999968-35] Lua error in package.lua at line 80: module 'strict' not found.

[pmid10100611-36] Lua error in package.lua at line 80: module 'strict' not found.

[pmid9030619-37] Lua error in package.lua at line 80: module 'strict' not found.

[pmid11112705-38] Lua error in package.lua at line 80: module 'strict' not found.

[1]

[2]

[3]

[4]

[§ 1]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

STX1A

Contents

Function

Clinical significance

Interactive pathway map

Interactions

See also

References

Further reading

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Tools