APPL2

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4H8S
Identifiers
Symbols	APPL2 ; DIP13B
External IDs	OMIM: 606231 MGI: 2384914 HomoloGene: 10046 GeneCards: APPL2 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • cytoplasm • endosome membrane • NuRD complex • early endosome membrane • extracellular exosome Biological process • cell cycle • signal transduction • cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE APPL2 218218 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55198	216190
Ensembl	ENSG00000136044	ENSMUSG00000020263
UniProt	Q8NEU8	Q8K3G9
RefSeq (mRNA)	NM_001251904	NM_145220
RefSeq (protein)	NP_001238833	NP_660255
Location (UCSC)	Chr 12: 105.17 – 105.24 Mb	Chr 10: 83.6 – 83.65 Mb
PubMed search	[1]	[2]

DCC-interacting protein 13-beta is a protein that in humans is encoded by the APPL2 gene.

Model organisms

Appl2 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Micronucleus test	Normal
Heart weight	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Salmonella infection	Normal
Citrobacter infection	Normal
All tests and analysis from

Model organisms have been used in the study of APPL2 function. A conditional knockout mouse line, called Appl2^{tm1a(KOMP)Wtsi} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on mutant mice, but no significant abnormalities were observed.