Alpha/beta hydrolase fold
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A bacterial lipase, one of this family members
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| Identifiers | |||||||||
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| Symbol | Abhydrolase_1 | ||||||||
| Pfam | PF00561 | ||||||||
| InterPro | IPR000073 | ||||||||
| SCOP | 1ede | ||||||||
| SUPERFAMILY | 1ede | ||||||||
| OPM superfamily | 135 | ||||||||
| OPM protein | 1qge | ||||||||
| CDD | cl21494 | ||||||||
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In molecular biology, the alpha/beta hydrolase fold is common to a number of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function.[1] The core of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8 beta strands connected by 6 alpha helices.[1][2] The enzymes are believed to have diverged from a common ancestor, preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best-conserved structural features of the fold.
This catalytic domain is found in a very wide range of enzymes which do not share obvious sequence similarity. The alpha/beta hydrolase fold includes proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases.[3]
Contents
Database
The ESTHER database provides a large collection of information about this family of proteins.[4]
Subfamilies
Human proteins containing this domain
ABHD10; ABHD11; ABHD12; ABHD12B; ABHD13; ABHD2; ABHD3; ABHD4; ABHD5; ABHD6; ABHD7; ABHD8; ABHD9; BAT5; BPHL; C20orf135; EPHX1; EPHX2; FAM108B1; LIPA; LIPF; LIPJ; LIPK; LIPM; LIPN; MEST; MGLL; PPME1; SERHL; SERHL2; SPG21; CES1; CES2; C4orf29
See also
- Serine hydrolase - an enzyme family that is composed largely of proteins with alpha-beta hydrolase folds
