Anthranilate-based insect repellents
Anthranilate-based insect repellents include methyl anthranilate, N,N-dimethylanthranilic acid (DMA), ethyl anthranilate (EA), and butyl anthranilate (BA). Chemically, they are esters of anthranilic acid. These compounds are approved by the US Food and Drug Administration (FDA) for use as food additives.[citation needed] The compounds repel both fruit flies and mosquitos. The compounds target the same neurons that respond to DEET. The receptors are located on part of the antennae known as the sacculus.[1][2]
MDA and EA repel mosquitos from feeding on humans, while EA and BA repel them from depositting eggs in water [3][4]
Identification
The compounds were the only ones among approximately 500,000 that activated those receptors and were from natural sources that were already approved by the FDA for use as food additives.[1]
Applications
The compounds are being evaluated for human use as mosquito repellents and also for use in agriculture.[1]
