Betrixaban
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| Systematic (IUPAC) name | |
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N-(5-chloropyridin-2-yl)-2-([4-(N,N-dimethylcarbamimidoyl)benzoyl]amino)-5-methoxybenzamide
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| Identifiers | |
| CAS Number | 330942-05-7  |
| ATC code | none |
| PubChem | CID: 10275777 |
| ChemSpider | 18981107  |
| UNII | 74RWP7W0J9 |
| ChEMBL | CHEMBL512351 |
| Chemical data | |
| Formula | C23H22ClN5O3 |
| Molecular mass | 451.905 g/mol |
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Betrixaban (INN, codenamed PRT-054,021) is an anticoagulant drug which acts as a direct factor Xa inhibitor.[1] It is potent, orally active and highly selective for factor Xa, being selected from a group of similar compounds for its low hERG affinity.[2] Betrixaban has undergone human clinical trials for prevention of embolism after knee surgery,[3] and prevention of stroke following atrial fibrillation,[4] with promising results.[5] Betrixaban is currently being studied in a human clinical trial for extended duration thromboprophylaxis to prevent venous thromboembolism in acute medically ill patients.[6] Joint development with Portola was discontinued in 2011 by Merck.[7] Betrixaban is now being developed by Portola Pharmaceuticals.
See also
References
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