Blood–ocular barrier
From Infogalactic: the planetary knowledge core
The blood–ocular barrier is a barrier created by endothelium of capillaries of the retina and iris, ciliary epithelium and retinal pigment epithelium.[1] It is a physical barrier between the local blood vessels and most parts of the eye itself, and stops many substances including drugs from traveling across it.[2] Inflammation can break down this barrier allowing drugs and large molecules to penetrate into the eye.[3] As the inflammation subsides, this barrier usually returns.
It consists of the following components:
- Blood-aqueous barrier: the ciliary epithelium and capillaries of the iris.[2]
- Blood-retinal barrier: non-fenestrated capillaries of the retinal circulation and tight-junctions between retinal epithelial cells preventing passage of large molecules from choriocapillaris into the retina.[4][5]
See also
References
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