CBLB (gene)
From Infogalactic: the planetary knowledge core
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene.[1][2] CBLB is a member of the CBL gene family.
Function
CBL-B functions as a negative regulator of T-cell activation.[3] CBL-B expression in T cells causes ligand-induced T cell receptor down-modulation, controlling the activation degree of T cells during antigen presentation.[4][5]
Clinical significance
Mutation of the CBLB gene has been associated with autoimmune conditions such as type 1 diabetes.[6][7]
Interactions
CBLB has been shown to interact with:
- CRKL,[8]
- Epidermal growth factor receptor,[9][10]
- Grb2,[8][11]
- NEDD4,[12]
- PIK3R1,[8][11] and
- SH3KBP1.[13]
References
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Further reading
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