CHST7

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
Identifiers
Symbols	CHST7 ; C6ST-2; GST-5
External IDs	OMIM: 300375 MGI: 1891767 HomoloGene: 10531 GeneCards: CHST7 Gene
EC number	2.8.2.17
Gene ontology Molecular function • N-acetylglucosamine 6-O-sulfotransferase activity • chondroitin 6-sulfotransferase activity Cellular component • Golgi membrane • integral component of membrane Biological process • carbohydrate metabolic process • polysaccharide metabolic process • N-acetylglucosamine metabolic process • sulfur compound metabolic process • glycosaminoglycan metabolic process • chondroitin sulfate metabolic process • chondroitin sulfate biosynthetic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CHST7 206756 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56548	60322
Ensembl	ENSG00000147119	ENSMUSG00000037347
UniProt	Q9NS84	Q9EP78
RefSeq (mRNA)	NM_019886	NM_021715
RefSeq (protein)	NP_063939	NP_068361
Location (UCSC)	Chr X: 46.57 – 46.6 Mb	Chr X: 20.06 – 20.1 Mb
PubMed search	[1]	[2]

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.

Function

This gene belongs to the sulfotransferase gene family. Sulfotransferases generate sulfated glycosaminoglycan (GAG) moities during chondroitin sulfate biosynthesis. They create considerable structural diversity among chondroitin sulfates by transferring sulfate with remarkable specificity for the underlying oligosaccharide substrate. This gene product mainly transfers sulfate to N-acetylgalactosamine. The regulated expression of each member of this gene family may be an important determinant of sulfated GAGs expression and the associated function of chondroitin sulfates as regulators of many biologic processes. This gene is part of a gene cluster on chromosome Xp11.23.