DNA replication factor CDT1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). DNA replication factor Cdt1 is a protein that in humans is encoded by the CDT1 gene.[1][2][3]
The protein encoded by this gene is a key licensing factor which, along with the protein Cdc6, functions to license DNA by forming the pre-replication complex (pre-RC). Its activity during the cell cycle is tightly regulated by its association with the protein geminin, which both inhibits Cdt1 activity during S phase in order to prevent re-replication of DNA and prevents it from ubiquitination and subsequent proteolysis.[4]
Orthologs
CDT1 belongs to a family of replication proteins conserved from yeast to humans. Examples of orthlogs in other species include:
- S. pombe – cdt1 (cdc10-dependent transcript 1)[5]
- Drosophila melanogaster – 'double parked' or Dup[6]
- Xenopus laevis - Cdt1[7]
Interactions
DNA replication factor CDT1 has been shown to interact with SKP2.[8] Cdt1 is recruited by the origin recognition complex in origin licensing. Null-mutations for Cdt1 are lethal in yeast; the spores undergo mitosis without DNA replication. The overexpression of Cdt1 causes rereplication in H. sapiens, which activates the Chk1 pathway, preventing entry into mitosis.[9]
References
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Further reading
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