DDAIP

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DDAIP
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Systematic (IUPAC) name
2-Dimethylaminopropionic acid dodecyl ester
Pharmacokinetic data
Bioavailability <1% (topical)
Protein binding >99%
Metabolism Esterase mediated
Biological half-life 5 hours
Excretion Urinary
Identifiers
CAS Number 224297-43-2 YesY
259685-49-9 (HCl)
PubChem CID: 3025823
ChemSpider 2291478
UNII 6679UF28DO YesY
Synonyms Dodecyl 2-N,N-dimethylaminopropionate; Dodecyl-2-(dimethylamino)propionate; N,N-Dimethylalanine dodecyl ester
Chemical data
Formula C17H36ClNO2
Molecular mass 321.93 g/mol
  • CCCCCCCCCCCCOC(=O)C(C)N(C)C
  • InChI=1S/C17H35NO2/c1-5-6-7-8-9-10-11-12-13-14-15-20-17(19)16(2)18(3)4/h16H,5-15H2,1-4H3
  • Key:HSMMSDWNEJLVRY-UHFFFAOYSA-N
  (verify)

DDAIP is a pharmaceutical ingredient added to topical products to increase penetration through the skin. Chemically, DDAIP is an ester of N,N-dimethylalanine and dodecanol. DDAIP is typically formulated as its hydrochloride salt (DDAIP.HCl). This salt is a white crystalline solid with a melting range of 88-93°C and is an amphiphilic molecule with a pKa of 4.87 that is soluble in water up to about 40% w/v. DDAIP is proprietary to NexMed USA, a subsidiary of Apricus Biosciences.[1]

Mechanism of action

DDAIP is a permeation enhancer[2] that temporarily changes the permeation dynamics of the lipid bilayer and opens up the tight junctions between skin cells so active drug molecules can be rapidly absorbed through the skin into systemic circulation.[3] It can also improve the solubility of compounds resulting in enhanced drug permeation.[4]

Clinical use

DDAIP hydrochloride is a functional inactive excipient currently used in the topical drug Vitaros, an alprostadil vasodilator cream used to treat erectile dysfunction. It is also used in MycoVa,[5] a terbinafine antifungal nail lacquer for onychomycosis currently in phase-III clinical trials.

Safety

Overall, about 5,000 patients have been exposed to this compound with no serious adverse events recorded. DDAIP is primarily metabolized by esterases on cell surfaces and plasma to N,N-dimethylalanine, which is further demethylated to alanine; and dodecanol which is oxidized to lauric acid, both naturally occurring compounds already present in the body.

References

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