Dihydropteroate
From Infogalactic: the planetary knowledge core
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Names | |
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IUPAC name
4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoic acid
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Identifiers | |
2134-76-1 | |
1226443 | |
ChEBI | CHEBI:4581 |
ChemSpider | 165 |
Jmol 3D model | Interactive image Interactive image |
KEGG | C00921 |
PubChem | 170 |
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Properties | |
C14H14N6O3 | |
Molar mass | 314.3 g/mol |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Dihydropteroate is a pterin created from para-aminobenzoic acid (PABA) by the enzyme dihydropteroate synthase. It is an important intermediate in folate synthesis.
Bacteriostatic agents, such as sulfonamides, target dihydropteroate synthetase. The effect of dihydropteroate synthetase inhibition is comparable to that of dihydrofolate reductase inhibition by trimethoprim, another bacteriostatic agent. Together these two drugs - trimethoprim-sulfamethoxazole [TMP-SMX] - are commonly used to treat recurrent urinary tract, Shigella, Salmonella, and Pneumocystis jivoreci infections.
See also
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