Ethyl glucuronide

Ethyl glucuronide

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Systematic (IUPAC) name
(2S,3S,4S,5R,6S)-6-ethoxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Clinical data
Routes of administration	N/A
Pharmacokinetic data
Biological half-life	2-3 hours approx
Identifiers
CAS Number	17685-04-0 Y
PubChem	CID: 152226
ChemSpider	134174 N
Chemical data
Formula	C8H14O7
Molecular mass	222.193 g/mol
SMILES CCO[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C(=O)O)O)O)O
InChI InChI=1S/C8H14O7/c1-2-14-8-5(11)3(9)4(10)6(15-8)7(12)13/h3-6,8-11H,2H2,1H3,(H,12,13)/t3-,4-,5+,6-,8?/m0/s1 N Key:IWJBVMJWSPZNJH-XWBUKDKVSA-N N
NY (what is this?)  (verify)

Ethyl glucuronide (EtG) is a metabolite of ethyl alcohol which is formed in the body by glucuronidation following exposure to ethanol, usually from drinking alcoholic beverages. It is used as a biomarker to test for ethanol use and to monitor to document alcohol abstinence in situations where drinking is prohibited, such as by the military, in alcohol treatment programs, in professional monitoring programs (health professionals, attorneys, airline pilots in recovery from addictions), in schools, liver transplant clinics, or in recovering alcoholic patients. In addition to its use to monitor abstinence and detect drinking EtG also has potential for monitoring amount of alcohol use over time because it can be detected in hair and nails, though the effectiveness of this has not yet been proven.

A disadvantage of the test is that because EtG can be detected in samples at very low levels, it can also be positive after exposure to alcohol from non-beverage sources, or incidental exposure, which can lead to false positives. The sources of possible exposure in the environment are numerous and include alcohol in mouthwash, foods, over-the-counter medications, and even from inhalation of alcohol from topical use. It is impossible with this biomarker to distinguish small amounts of drinking from extraneous exposure to alcohol.

Hair Testing Controversy

A growing number of articles are documenting the high sensitivity and specificity of hair (or nail) EtG for detection of heavy drinking.

EtG testing in hair specimens was previously attempted by laboratories in the United Kingdom, but has suffered from numerous lawsuits. Due to the concerns of legal risk, few laboratories offer this type of testing anymore, as it has been determined to be unreliable and unsupportable. The Society of Hair Testing also notes the limitations of EtG, stating that this form of testing can determine "chronic excessive alcohol consumption only. This consensus is not applicable for determination of abstinence from alcohol or moderate consumption of alcohol." SoFT also states that "It is not advisable to use the results of the hair testing for alcohol markers in isolation," supporting the belief that additional testing evidence is required to properly identify an individual's alcohol usage. As such, this form of testing is only applicable for scenarios where severe alcohol abuse is present.

The U.S. Substance Abuse and Mental Health Services Administration has cautioned that the test is "scientifically unsupportable as the sole basis for legal or disciplinary action" because the highly sensitive tests "are not able to distinguish between alcohol absorbed into the body from exposure to many common commercial and household products containing alcohol and from the actual consumption of alcohol."

See also

Other experimental serologic tests (biomarkers) for recent alcohol use include 5-hydroxytryptophol, ethyl sulfate, phosphatidyl ethanol, sialic acid level, β-hexosaminidase, mitochondrial AST levels, and alcohol metabolites such as erythrocyte acetaldehyde and acetaldehyde adducts.