FBXW8

F-box and WD repeat domain containing 8
Identifiers
Symbols	FBXW8 ; FBW6; FBW8; FBX29; FBXO29; FBXW6
External IDs	OMIM: 609073 MGI: 1923041 HomoloGene: 17731 GeneCards: FBXW8 Gene
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding Cellular component • cytoplasm • Golgi apparatus • SCF ubiquitin ligase complex • Cul7-RING ubiquitin ligase complex • perinuclear region of cytoplasm • 3M complex Biological process • Golgi organization • cell proliferation • protein ubiquitination • positive regulation of dendrite morphogenesis • spongiotrophoblast layer development • labyrinthine layer blood vessel development Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE FBXW8 gnf1h08761 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26259	231672
Ensembl	ENSG00000174989	ENSMUSG00000032867
UniProt	Q8N3Y1	Q8BIA4
RefSeq (mRNA)	NM_012174	NM_172721
RefSeq (protein)	NP_036306	NP_766309
Location (UCSC)	Chr 12: 116.91 – 117.03 Mb	Chr 5: 118.06 – 118.16 Mb
PubMed search	[1]	[2]

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.