GAL3ST3

Galactose-3-O-sulfotransferase 3
Identifiers
Symbols	GAL3ST3 ; GAL3ST-3; GAL3ST2
External IDs	OMIM: 608234 MGI: 3617843 HomoloGene: 57198 GeneCards: GAL3ST3 Gene
Gene ontology Molecular function • galactosylceramide sulfotransferase activity • carbohydrate binding • 3'-phosphoadenosine 5'-phosphosulfate binding • galactose 3-O-sulfotransferase activity • proteoglycan sulfotransferase activity Cellular component • integral component of membrane • Golgi cisterna membrane Biological process • monosaccharide metabolic process • sulfur compound metabolic process • oligosaccharide metabolic process • proteoglycan biosynthetic process • poly-N-acetyllactosamine metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	89792	545276
Ensembl	ENSG00000175229	ENSMUSG00000047658
UniProt	Q96A11	P61315
RefSeq (mRNA)	NM_033036	NM_001024717
RefSeq (protein)	NP_149025	NP_001019888
Location (UCSC)	Chr 11: 66.04 – 66.05 Mb	Chr 19: 5.3 – 5.31 Mb
PubMed search	[1]	[2]

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3.