GRIN2A

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Glutamate [NMDA] receptor subunit epsilon-1 is a protein that in humans is encoded by the GRIN2A gene.[1]

Function

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).[2]

Associations

Variants of the gene are associated with the protective effect of coffee on Parkinson's disease.[3][4]

Mutations in GRIN2A are associated to refractory epilepsy .[5]

Interactions

GRIN2A has been shown to interact with:

See also

References

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Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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