Gammaretrovirus core encapsidation signal
From Infogalactic: the planetary knowledge core
| Gammaretrovirus core encapsidation signal | |
|---|---|
| 220px | |
| Predicted secondary structure and sequence conservation of Gammaretro_CES | |
| Identifiers | |
| Symbol | Gammaretro_CES |
| Rfam | RF00374 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Eukaryota; Viruses |
| SO | 0000233 |
File:PDB 1s9s EBI.png
A 3D representation of a Gammaretrovirus core encapsidation signal. This is a view of the NMR structure for the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus.[1]
File:PDB 1u6p EBI.jpg
A 3D representation of a Gammaretrovirus. This structure shows the packaging of the dimeric genome of Moloney murine leukaemia virus, of which the encapsidation signal forms a part.[2]
The Gammaretrovirus core encapsidation signal is an RNA element known to be essential for stable dimerisation and efficient genome packaging during virus assembly.[1] Dimerisation of the viral RNA genomes is proposed to act as an RNA conformational switch which exposes conserved UCUG elements and enables efficient genome encapsidation.[2] The structure of this element is composed of three stem-loops. Two of the stem-loops called SL-C and SL-D form a single co-axial extend helix.
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