HMGN3

High mobility group nucleosomal binding domain 3
Identifiers
Symbols	HMGN3 ; PNAS-24; PNAS-25; TRIP7
External IDs	OMIM: 604502 MGI: 2138069 HomoloGene: 130417 GeneCards: HMGN3 Gene
Gene ontology Molecular function • nucleosomal DNA binding • thyroid hormone receptor binding Cellular component • chromatin • nucleoplasm • cytoplasm Biological process • biological_process • chromatin modification • positive regulation of transcription from RNA polymerase II promoter • regulation of insulin secretion involved in cellular response to glucose stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9324	94353
Ensembl	ENSG00000118418	ENSMUSG00000066456
UniProt	Q15651	Q9DCB1
RefSeq (mRNA)	NM_001201362	NM_026122.4
RefSeq (protein)	NP_001188291	NP_080398.1
Location (UCSC)	Chr 6: 79.2 – 79.23 Mb	Chr 9: 83 – 83.04 Mb
PubMed search	[1]	[2]

High mobility group nucleosome-binding domain-containing protein 3 is a protein that in humans is encoded by the HMGN3 gene.

Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Two transcript variants encoding different isoforms have been found for this gene.

External links

• FactorBook HMGN3