Infinite-alleles model
From Infogalactic: the planetary knowledge core
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The Japanese geneticist Motoo Kimura and American geneticist James F. Crow (1964) introduced the infinite alleles model, an attempt to examine the dynamics of mutations. It is built on a set of assumptions:
- Each mutation is unique
- Mutations are not reversible
This means that two alleles identical by state must also be identical by descent. Therefore, the frequency of homozygosity is equal to the frequency of autozygosity.
References
External links
- https://scholar.google.co.uk/scholar?q=Infinite-alleles+model&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ei=L7GFVe--JoaU7Aa-5oGoCg&ved=0CB8QgQMwAA
- Details on the various assumptions used in computing TMRCA - Infinite-alleles model, The University of Arizona
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