Juno Therapeutics
 |
|
| Public | |
| Traded as | NASDAQ: JUNO[1] |
| Industry | Biotechnology |
| Founded | 2013[2] |
| Headquarters | Seattle, WA |
|
Key people
|
Hans Bishop (CEO & President) Steve Harr, M.D. (CFO) |
| Website | junotherapeutics |
Juno Therapeutics is a biopharmaceutical company founded in 2013 through a collaboration of the Fred Hutchinson Cancer Research Center, Memorial Sloan-Kettering Cancer Center and pediatrics partner Seattle Children's Research Institute. The company was launched with an initial investment of $120 million, with a remit to develop a pipeline of cancer immunotherapy drugs.[2] The company raised $300 million through private funding and a further $265 million through their IPO.
Company History
In December 2014 the company signed an agreement with Opus Bio, Inc for a chimeric antigen receptor (CAR-T) cell product candidate targeting CD22.[3]
In April 2015 the company entered into a collaboration with MedImmune (a subsidiary of Astra Zeneca) investigating combination treatments for cancer. The trials will assess combinations of MEDI4736 and one of Junos CD19 directed chimeric antigen receptor T cell candidates.[4] In May 2015, the company announced its intention to acquire Stage Cell Therapeutics for up to $223 million.[5] Later in the same month the company launched a collaboration, with Editas Medicine, to create CAR-T and high-affinity T cell receptor therapies to treat cancer, with the potential to generate up to $737 million-plus for Editas.[6] In June, the company announced it would acquire X-Body for more than $44 million.[7] In June, the company announced a 10-year partnership with Celgene valued at $1 billion.[8] As part of the deal Celgene will pay Juno $150 million and acquire 9.1 million new Juno shares (valued at $93, existing Juno shares rose 26% to $58.38). Celgene will gain the right to sell Juno’s therapies around the world. This partnership suprasses the previous highest record when Pfizer agreed to a deal with Merck KGaA in 2014.[9]
In January 2016 Juno announced it had acquired AbVitro, allowing it to use next-generation single cell sequencing platforms to compliment its ability to create T cells engineered to target a broad array of cancer targets.[10]
Pipeline
| Drug | Notes | Ref |
|---|---|---|
| JCAR014 | Currently in Phase I/II trials at the Fred Hutchison Cancer Research Center, tested for relapsed or refractory chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and acute lymphoblastic leukemia | [11] |
| JCAR015 | Designed to treat acute lymphoblastic leukemia, currently in Phase I trials with Memorial Sloan Kettering Cancer Centre, Received Orphan Drug Designation By FDA in November 2014. | [12] |
| JCAR017 | Currently in Phase I/II trials at Seattle Children's Hospital, tested for pediatric and young adult relapsed/refractory CD19 positive leukemia | [13] |
| JTCR016 | Currently in Phase I for adult acute myeloid leukemia | [14] |
| JCAR023 | Currently in Phase I for Pediatric neuroblastoma | [14] |
| JCAR018 | Currently in Phase I for non-Hodgkin's lymphoma and acute lymphoblastic leukemia | [14] |
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ http://www.genengnews.com/gen-news-highlights/juno-s-abvitro-acquisition-adds-sequencing-to-repertoire/81252218/
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 14.0 14.1 14.2 Lua error in package.lua at line 80: module 'strict' not found.
