KIR3DL3

Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1M4K, 4N8V
Identifiers
Symbols	KIR3DL3 ; CD158Z; KIR2DS2; KIR3DL7; KIR44; KIRC1
External IDs	OMIM: 610095 HomoloGene: 77448 GeneCards: KIR3DL3 Gene
Gene ontology Molecular function • receptor activity Cellular component • plasma membrane • integral component of membrane Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	115653	245615
Ensembl	ENSG00000242019	ENSMUSG00000057439
UniProt	P43631	E9Q1D8
RefSeq (mRNA)	NM_153443	NM_177748
RefSeq (protein)	NP_703144	NP_808416
Location (UCSC)	Chr 19: 54.72 – 54.74 Mb	Chr X: 136.45 – 136.54 Mb
PubMed search	[1]	[2]

Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the KIR3DL3 gene.

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.