MRPS18A

Mitochondrial ribosomal protein S18A
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Symbols	MRPS18A ; HumanS18b; MRP-S18-3; MRPS18-3; S18bmt
External IDs	OMIM: 611981 MGI: 1915815 HomoloGene: 32391 GeneCards: MRPS18A Gene
Gene ontology Molecular function • structural constituent of ribosome Cellular component • mitochondrial inner membrane • mitochondrial small ribosomal subunit Biological process • translation • organelle organization • mitochondrial translation • mitochondrial translational initiation • mitochondrial translational elongation • mitochondrial translational termination Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE MRPS18A 218385 at tn.png
File:PBB GE MRPS18A 221693 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55168	68565
Ensembl	ENSG00000096080	ENSMUSG00000023967
UniProt	Q9NVS2	Q99N85
RefSeq (mRNA)	NM_001193343	NM_026768
RefSeq (protein)	NP_001180272	NP_081044
Location (UCSC)	Chr 6: 43.67 – 43.69 Mb	Chr 17: 46.11 – 46.13 Mb
PubMed search	[1]	[2]

28S ribosomal protein S18a, mitochondrial is a protein that in humans is encoded by the MRPS18A gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p.