MYO15A

Myosin XVA
Identifiers
Symbols	MYO15A ; DFNB3; MYO15
External IDs	OMIM: 602666 MGI: 1261811 HomoloGene: 56504 GeneCards: MYO15A Gene
Gene ontology Molecular function • motor activity • actin binding • calmodulin binding • ATP binding Cellular component • cytoplasm • myosin complex • stereocilium • extracellular exosome Biological process • sensory perception of sound • locomotory behavior • metabolic process • inner ear morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51168	17910
Ensembl	ENSG00000091536	ENSMUSG00000042678
UniProt	Q9UKN7	Q9QZZ4
RefSeq (mRNA)	NM_016239	NM_001103171
RefSeq (protein)	NP_057323	NP_001096641
Location (UCSC)	Chr 17: 18.11 – 18.18 Mb	Chr 11: 60.47 – 60.53 Mb
PubMed search	[1]	[2]

Myosin-XV is a protein that in humans is encoded by the MYO15A gene.

Gene

Read-through transcript containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined.

Function

This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea.

Clinical significance

Mutations in this gene have been associated with profound, congenital, neurosensory, non syndromic deafness . This gene is located within the Smith-Magenis syndrome region on chromosome 17.