PAK3
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Serine/threonine-protein kinase PAK 3 is an enzyme that in humans is encoded by the PAK3 gene.[1][2][3]
Contents
Function
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity.[3]
Clinical significance
A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.[3]
Interactions
PAK3 has been shown to interact with RAC1.[4]
References
Further reading
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External links
- PAK3 Info with links in the Cell Migration Gateway
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PDB gallery
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This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it. |
