POLR2J2

Polymerase (RNA) II (DNA directed) polypeptide J2
Identifiers
Symbols	POLR2J2 ; HRPB11B; RPB11b1
External IDs	OMIM: 609881 HomoloGene: 129653 GeneCards: POLR2J2 Gene
Gene ontology Molecular function • DNA binding • DNA-directed RNA polymerase activity • protein dimerization activity Cellular component • nucleus Biological process • transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE POLR2J2 216242 x at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	246721	n/a
Ensembl	ENSG00000228049	n/a
UniProt	Q9GZM3	n/a
RefSeq (mRNA)	NM_032958	n/a
RefSeq (protein)	NP_116581	n/a
Location (UCSC)	Chr 7: 102.67 – 102.67 Mb	n/a
PubMed search	[1]	n/a

DNA directed RNA polymerase II polypeptide J-related gene, also known as POLR2J2, is a human gene.

This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.