RAD17

Cell cycle checkpoint protein RAD17 is a protein that in humans is encoded by the RAD17 gene.

Function

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported.

Interactions

RAD17 has been shown to interact with:

• Ataxia telangiectasia and Rad3 related,
• Ataxia telangiectasia mutated,
• HUS1,
• NHP2L1,
• POLE,
• RAD1 homolog, and
• RAD9A.