RNF128

Ring finger protein 128, E3 ubiquitin protein ligase
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3ICU
Identifiers
Symbols	RNF128 ; GRAIL
External IDs	OMIM: 300439 MGI: 1914139 HomoloGene: 11337 GeneCards: RNF128 Gene
EC number	6.3.2.-
Gene ontology Molecular function • protein binding • zinc ion binding • ligase activity • ubiquitin protein ligase activity Cellular component • late endosome • endoplasmic reticulum • Golgi apparatus • cytoskeleton • integral component of membrane • perinuclear region of cytoplasm Biological process • regulation of protein stability • negative regulation of cytokine biosynthetic process • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • protein localization to lysosome • positive regulation of protein catabolic process in the vacuole Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE RNF128 219263 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79589	66889
Ensembl	ENSG00000133135	ENSMUSG00000031438
UniProt	Q8TEB7	Q9D304
RefSeq (mRNA)	NM_024539	NM_001254761
RefSeq (protein)	NP_078815	NP_001241690
Location (UCSC)	Chr X: 106.69 – 106.8 Mb	Chr X: 139.56 – 139.67 Mb
PubMed search	[1]	[2]

E3 ubiquitin-protein ligase RNF128 is an enzyme that in humans is encoded by the RNF128 gene.

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Interactions

RNF128 has been shown to interact with CD154 and OTUB1.