RNF139

Ring finger protein 139
Identifiers
Symbols	RNF139 ; HRCA1; RCA1; TRC8
External IDs	OMIM: 603046 MGI: 1923091 HomoloGene: 5222 GeneCards: RNF139 Gene
Gene ontology Molecular function • protease binding • ubiquitin-protein transferase activity • receptor activity • protein binding • zinc ion binding • ligase activity • ubiquitin-like protein transferase activity Cellular component • endoplasmic reticulum • integral component of membrane • Derlin-1 retrotranslocation complex Biological process • negative regulation of cell proliferation • protein ubiquitination • negative regulation of translation • regulation of protein ubiquitination • protein destabilization • ERAD pathway • regulation of ER to Golgi vesicle-mediated transport • regulation of protein processing • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE RNF139 209510 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11236	75841
Ensembl	ENSG00000170881	ENSMUSG00000037075
UniProt	Q8WU17	Q7TMV1
RefSeq (mRNA)	NM_007218	NM_175226
RefSeq (protein)	NP_009149	NP_780435
Location (UCSC)	Chr 8: 124.47 – 124.49 Mb	Chr 15: 58.89 – 58.9 Mb
PubMed search	[1]	[2]

RING finger protein 139 is a protein that in humans is encoded by the RNF139 gene.

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.