RNPS1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). RNA-binding protein with serine-rich domain 1 is a protein that in humans is encoded by the RNPS1 gene.[1][2][3]
Function
This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Two splice variants have been found for this gene; both variants encode the same protein.[3]
Interactions
RNPS1 has been shown to interact with SART3[4] and Pinin.[5][6]
References
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Further reading
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