SLC3A2
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4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene.[1][2]
SLC3A2 comprises the light subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of differentiation 98).[3][4]
Function
SLC3A2 is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha-amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]
LAT1 is a heterodimeric membrane transport protein that preferentially transports neutral branched (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids.[5] LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues.[5]
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:
- 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene)[6]
- CD98 light subunit protein encoded by the SLC7A5 gene[7]
Interactions
SLC3A2 has been shown to interact with SLC7A7.[8]
See also
References
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Further reading
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External links
- Large Neutral Amino Acid-Transporter 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Amino Acid Transport System L at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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