Sivelestat

Sivelestat
	File:Sivelestat.png
Systematic (IUPAC) name
	N-{2-[({4-[(2,2-dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only);
Routes of; administration	IV
Identifiers
CAS Number	127373-66-4
ATC code	none
PubChem	CID: 107706
IUPHAR/BPS	6441
ChemSpider	96875
UNII	DWI62G0P59
KEGG	D03788
ChEMBL	CHEMBL76688
Chemical data
Formula	C20H22N2O7S
Molecular mass	434.46 g/mol
	SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O ;
	InChI InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24) ; Key:BTGNGJJLZOIYID-UHFFFAOYSA-N ;
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Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase.^[1]

It is used in the treatment of acute respiratory failure^[2] and preliminary studies show it may also improve neuropathic pain.^[3]

Synthesis

Sivelestat is synthesised as follows:^[4]

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