TASP1

Taspase, threonine aspartase, 1
250px PDB rendering based on 2a8i.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2A8I, 2A8J, 2A8L, 2A8M
Identifiers
Symbols	TASP1 ; C20orf13; dJ585I14.2
External IDs	OMIM: 608270 MGI: 1923062 HomoloGene: 9795 ChEMBL: 6153 GeneCards: TASP1 Gene
EC number	3.4.25.-
Gene ontology Molecular function • threonine-type endopeptidase activity Biological process • proteolysis • positive regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE TASP1 219443 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55617	75812
Ensembl	ENSG00000089123	ENSMUSG00000039033
UniProt	Q9H6P5	Q8R1G1
RefSeq (mRNA)	NM_017714	NM_001159640
RefSeq (protein)	NP_060184	NP_001153112
Location (UCSC)	Chr 20: 13.39 – 13.64 Mb	Chr 2: 139.83 – 140.07 Mb
PubMed search	[1]	[2]

Threonine aspartase 1 is an enzyme that in humans is encoded by the TASP1 gene.

Function

This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Cleavage of TFIIA has been found to drive spermatogenesis.

Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Clinical significance

Taspase1 is overexpressed in primary human cancers and functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis. Therefore, Taspase1 may serve as a novel anti-cancer therapeutic target.