Template:PBB/1280

Collagen, type II, alpha 1
250px Chordin-like Cysteine-rich Repeat (VWC module) from Collagen IIA. PDB 1u5m
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1U5M, 2FSE, 2SEB
Identifiers
Symbols	COL2A1 ; ANFH; AOM; COL11A3; SEDC; STL1
External IDs	OMIM: 120140 HomoloGene: 55607 GeneCards: COL2A1 Gene
Gene ontology Molecular function • extracellular matrix structural constituent conferring tensile strength • identical protein binding • metal ion binding • platelet-derived growth factor binding Cellular component • extracellular region • collagen type II trimer • basement membrane • extracellular space • endoplasmic reticulum lumen • extracellular matrix Biological process • skeletal system development • cartilage condensation • tissue homeostasis • endochondral ossification • chondrocyte differentiation • heart morphogenesis • proteoglycan metabolic process • axon guidance • central nervous system development • visual perception • sensory perception of sound • regulation of gene expression • extracellular matrix disassembly • extracellular matrix organization • collagen fibril organization • collagen catabolic process • notochord development • inner ear morphogenesis • cartilage development • palate development • limb bud formation • embryonic skeletal joint morphogenesis • cartilage development involved in endochondral bone morphogenesis • otic vesicle development • cellular response to BMP stimulus • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1280	12824
Ensembl	ENSG00000139219	ENSMUSG00000022483
UniProt	P02458	P28481
RefSeq (mRNA)	NM_001844	NM_001113515
RefSeq (protein)	NP_001835	NP_001106987
Location (UCSC)	Chr 12: 47.97 – 48 Mb	Chr 15: 97.98 – 98 Mb
PubMed search	[1]	[2]